The evidence
A plant extract discovered in New Zealand, with three published human clinical trials behind it. Here is what those trials found — and, just as plainly, what they didn't.
How it works
Calocurb's active ingredient is Amarasate®, a bitter extract of the hops flower (Humulus lupulus) developed in New Zealand using food-grade supercritical CO₂ extraction. Its job is simple: switch on the appetite brake your body already has.
Taken about an hour before eating, the capsule carries the bitter Amarasate® compounds past the mouth and into the gut.
Your gut is lined with bitter taste receptors (TAS2Rs). When the bitter compounds reach them, they trigger — the same sensing system your tongue uses, working further down.
The gut releases your body's own appetite hormones — GLP-1, CCK and PYY — the natural "I've had enough" signals. You feel satisfied sooner, with less pull towards more.
Three published human trials
Most supplements lean on borrowed studies of an ingredient that's merely similar. Amarasate® itself has been through three human clinical trials at named New Zealand research institutions, each published in a peer-reviewed journal.
A randomised, double-blind, crossover trial in 30 men, each completing a 24-hour fast. In this clinical study, both doses tested — 200 mg and 500 mg — significantly reduced hunger (p<0.05). The usual lunchtime spike in hunger was absent on the active arm.
Honest note: this trial measured hunger, not hormones. The hormone measurements came two years later.
Walker E. et al., Nutrients 2019;11(11):2754.
A randomised crossover trial run by Plant & Food Research with the University of Auckland. In this clinical study, Amarasate® taken about an hour before a meal raised GLP-1 and CCK — the body's own fullness hormones — up to around six times basal levels, and participants ate roughly 13–17% less at the next meal.
Randomised crossover trial, 2021 — Plant & Food Research with the University of Auckland.
Thirty women took two doses during 24-hour fasts. In this clinical study, participants reported around 30% less hunger and around 40% fewer cravings, consumed around 18% fewer calories, and showed measured increases in CCK and PYY. The effects on hunger were larger in women than previously seen in men.
Obesity Pillars, 2024 — n=30 women, two doses, 24-hour fasts.
Read before you buy
Both columns matter. We would rather you buy on what's actually been demonstrated than on what a label implies.
| What the evidence shows | What it doesn't — yet |
|---|---|
| Shown: acute reductions in hunger, cravings and food intake, measured in clinical studies. | Not shown: there is no published long-term weight-loss trial. We won't tell you Calocurb is proven to deliver lasting weight loss, because that study hasn't been done. |
| Shown: measured rises in the body's own GLP-1, CCK and PYY — the appetite hormones, directly assayed. | Not shown: that it treats anything. Calocurb is a dietary supplement, not a medicine — it doesn't diagnose, treat, cure or prevent any disease. |
| Shown: three published human trials, run at reputable New Zealand research institutions, in peer-reviewed journals. | Not shown: a guarantee. Trial results are averages; individual results vary. |
If a long-term trial is published, we'll report it here — whichever way it goes.
Three published human trials, named institutions, and a 30-day money-back guarantee if it doesn't work for you.
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